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A very popular question asked about CBD is “Is it possible to overdose on CBD?”. Currently, there are no studies suggesting something fatal could happen to you from overdosing CBD. CBD is both not toxic, not addictive and safe. But like with anything, apply it correctly with the recommended dosage for your product, as going to high could put you at risk of the potential side effects. The best way to avoid these side effects is to start out with small doses, and then slowly work your up way if you notice no benefits or side effects. CBD is gaining popularity quickly, so more research is still ongoing. Today, we’re going to dive into some facts

If you enjoyed the video, make sure to leave a comment below and subscribe!

Sources:

https://www.healthline.com/health/CBD-reasons-it-doesnt-work#takeaway
https://edition.cnn.com/2019/05/21/health/heroin-opioid-addiction-cbd-study/index.html
https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
https://royalcbd.com/can-you-overdose-on-cbd/?__cf_chl_jschl_tk__=6ab5a5367e1c95f45efe32d70cefa144fa64b7aa-1598634020-0-AYynHEqqdBUeXmvmwBvaJa7XKN3gPLEkY63jVbuiC6GEdAdI002LVqUWL_dvzhLF79fZy-jm0r9jT3UY7riHzV3HLUSjOIG89ZvM1enzTHmBGmMwIwYSr6oYFlt0VqXJAkUzuYJQ7UKbxrkyv5ZXJn7HBGB73YvbPY-AaZn03TaLc68-aD_fbmKGAOUP

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CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety.

TRANSCRIPT:

CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own.

CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood.

CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy.

REFERENCES:

Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250

McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944

Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041

World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

Special thanks to Srikar Gade for help with fact-checking this video.

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Advertising and Affiliate Marketing Disclaimer: Some links in this video description may be affiliate links. This means if you click on the link and purchase an item, PetGuide360 may receive an affiliate commission. This is at no extra cost to you, and it helps us to continue providing valuable content. Our content, including the advice provided, is independent and not influenced by any advertiser or commercial initiative.

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Singer, songwriter, skateboarder, former member of the bands Conation and A Death in the Family; Jamie Hay shares about his lifetime of making music and skateboarding with his friends.

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Shan

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CBN vs CBD: How are They Different?

Original Post: https://www.newphaseblends.com/cbn-vs-cbd/
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Hundreds of cannabis compounds have been discovered, and only a few have received the spotlight they deserve.

Researchers have compared several cannabinoids and found some potential therapeutic benefits of multiple compounds, including CBN. Comparing the differences of CBN vs CBD is an interesting conversation that warrants more research. These two cannabinoids are popular, but offer different possible therapeutic benefits.

When comparing CBN vs CBD, both cannabinoids might look similar from a molecular standpoint, but these are two very different compounds. When looking at CBN and CBD, both have some similar potential therapeutic properties. We’re going to take some time to go over them, and see how they may be able to give you the relief you need.

What is CBN?

Cannabinol, or CBN, is a compound of cannabis (marijuana and hemp are both cannabis) famous for its non-intoxicating properties and a remarkable similarity with CBD. Cannabidiol, or CBD, is also a cannabinoid. CBN is a byproduct of degrading tetrahydrocannabinol, or THC. This simply means when THC ages and decays into an old compound, it turns into CBN.

CBN vs CBD: Oxidation

Let’s explore oxidation a little bit. Several different cannabinoids in the cannabis plant can oxidize into different compounds, depending on their makeup. Oxidation can happen in a few different ways. We’ll discuss the two most popular forms which are:

-Light exposure
-Time

Manufacturers can expose THC rich plants to extreme UV lighting in order to force the oxidation process. Over time, the excess exposure to UV lighting slowly turns the THC into CBN. The end result is a CBN rich product. Check out this picture of a UV light being used to exposure impurities in minerals. You’ll notice it uses a blue-ish spectrum of light, similar to a black light.

Time is also a key factor in oxidation of THC to CBN. Over time, THC will degrade and turn into CBN. That means CBN may exist in large amounts the older the plant is. Since we can’t (unfortunately) alter time, people will typically use the UV light method to force the oxidation process.

Currently, levels of CBN in cannabis depend on environmental factors instead of genetic factors of the particular strains. For this reason, there are currently no super-high CBN strains on the marketplace yet. This is one area of CBD vs CBN that is interesting, since there are several high CBD strains that exist.

Potential Benefits of CBN

CBN, back in 1896, was the first cannabinoid that was isolated in its purist form. People actually thought that CBN was responsible for the intoxicating effects of cannabis.

We now know that different forms of THC are, in fact, responsible for these effects. Originally CBN was the culprit! Interesting, isn’t it? This is one of the reasons that CBN is still heavily regulated in some areas. It wasn’t until later that the researchers showed CBN doesn’t produce intoxicating effects on its’ own.

In the topic of CBN vs CBD, the effects of CBN have not been thoroughly studied in human subjects – yet. Keep this in mind when you see products with CBN that make loads of medical claims. Sure, they could be true, but there aren’t enough scientific trials to substantiate the claims. That said, let’s talk more about the potential benefits of CBN.

Relieving Effects

Cannabinol has shown an ability to induce relaxing effects on the human brain and body. A study published in 2011 in the British Journal of Pharmacology made a claim that the combination of THC and CBN could produce a “tranquilizing” effects in humans. These two compounds are responsible for a large portion of the sedative effects people feel after using cannabis or marijuana products.

Aged cannabis products, or those with more exposure to heat and sunlight, showed better results in relaxing the human body. This is primarily because of the amount of THC that has converted to CBN, like we spoke about earlier.

The older cannabis products contain higher CBN content which makes them more useful for relieving purposes – or so it seems. Research with CBN is still being conducted, and refined, almost on a daily basis.

Anti-inflammatory and Anti-convulsant Properties

Researchers found out that a particular combination of CBN vs CBD can be a decent pain reliever. Scientists need to manufacture a CBN isolate to conduct proper research, as a specific breed of a heavily CBN enriched cannabis plant does not yet exist. This practice is one of the main hurdles for initiating further CBN-based investigations. In only two years, though, we have seen massive breakthroughs in developing CBD-rich strains.

CBN May Work as a Sleep Aid

The research in this particular area is lacking, but current results have shown CBN’s potential impacts on treating sleep disorders.

Pain Management: Marijuana Gummies for Chronic Pain

CBD and THC are both found in marijuana but only THC can cause the “high” feeling, while CBD has other effects.